MARCHIAFAVA-Bignami disease (MBD) is the symmetrical demyelination of the middle portion of the corpus callosum that can be observed in people with chronic alcoholism. Its evolution may be fatal or lead to various degrees of slowly evolving cognitive impairment. Patients with a benign course have been reported. Scattered reports exisit that it may respond to thiamine injections and therefore may be a variant of Wernicke's encephalopathy.ARCHNEUROL/VOL56, JAN1999
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